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Tyrosine motifs
 

  Kinase / Phosphatase motifs          

  Motif described in the literature
(phosphorylated residues in red)		 Features of motif described in the literature Link to original
article describing
the motif
  1  pYMXMAbl kinase substrate motif
  2  EDAIpYAbl kinase substrate motif
  3  XVIpYAAPFAbl kinase substrate motif
  4  EAIpYAAPFAbl kinase substrate motif
  5  EEIpYEEpYAbl kinase substrate motif
  6  EXIpYXXPXAbl kinase substrate motif
  7  EEIpYYYVHAbl kinase substrate motif
  8  ERIpYARTKAbl kinase substrate motif
  9  AEV[I/V/L/F]pYAA[P/F]FAbl kinase substrate motif
  10  pYXXYYALK kinase substrate motif
  11  pY[D/E]X[I/L/V/M]ALK kinase substrate motif
  12  [D/E]XXpYALK kinase substrate motif
  13  pYXXXX[F/Y]ALK kinase substrate motif
  14  EE[D/E]IpYFFFFCSK kinase substrate motif
  15  XXXIpY[M/I/F]FFFCSK kinase substrate motif
  16  EEEEpYFELV EGFR kinase substrate motif
  17  [E/D/R/A][D/E][D/E][E/D/I]pY[F/V/I/E][E/F/D][L/I/F/V]VEGFR kinase substrate motif
  18  X[D/E]pYXEGFR kinase substrate motif
  19  pYIPPEGFR kinase substrate motif
  20  X[D/E]pY[I/L/V]EGFR kinase substrate motif
  21  EEEIpYEEIEFes kinase substrate motif
  22  [E/A/D][E/A][E/A][I/E/V]pY[D/E][D/E][I/V/E][E/I/V]Fes kinase substrate motif
  23  EEEpYFFLFFGFR kinase substrate motif
  24  A[E/A]EEpY[F/V]F[L/F/M/I/V]FFGFR kinase substrate motif
  25  ME[E/N][I/V]pY[G/E]IFFFgr kinase substrate motif
  26  KKKSPGEpYVNIEFGIGF1 receptor kinase substrate motif
  27  pYMXMInsulin receptor kinase substrate motif
  28  EE[E/N/D]pY[M/F][M/F][M/F/I/E][M/F]Insulin receptor kinase substrate motif
  29  XEEEpYMMMMInsulin receptor kinase substrate motif
  30  KKSRGDpYMTMQIG Insulin receptor kinase substrate motif
  31  KKKLPATGDpYMNMSPVGDInsulin receptor kinase substrate motif
  32  pYXX[L/I/V]JAK2 kinase substrate motif
  33  pTPpYJNK kinase substrate motif
  34  XEXIpYGVLFLck kinase substrate motif
  35  EX[I/V/L/F]pY[G/A]V[L/V/F/I][F/L/V/I]Lck kinase substrate motif
  36  DEEIpY[E/G]ELXLyn kinase substrate motif
  37  [D/E]XXXXXXX[D/E]XXpYXXLXXXXXXXYXX[L/I]Lyn kinase substrate motif
  38  EEEEpYVFIXPDGFR kinase substrate motif
  39  [L/N][R/I]TpYPDGFR kinase substrate motif
  40  [D/E][D/E][D/E][D/E]pY[V/E/I]F[I/V/F]PDGFR kinase substrate motif
  41  [D/E]XXXXXXX[D/E]XXpYXXLXXXXXXXYXX[L/I]Src family kinase substrate motif
  42  [I/V/L/S]XpYXX[L/I]Src family kinase substrate motif
  43  pYMXMSrc kinase substrate motif
  44  YIpYGSFKSrc kinase substrate motif
  45  EEEIpY[G/E]EFDSrc kinase substrate motif
  46  D[D/E][E/D/G][I/V/L]pY[G/E]E[F/I]FSrc kinase substrate motif
  47  [D/E]XXXXXXX[D/E]XXpYXXLXXXXXXXYXX[L/I]Src kinase substrate motif
  48  [D/E][D/E][E/D/G][I/V/L]pY[G/E/D]E[F/I/L/V][D/E]Src kinase substrate motif
  49  pY[A/G/S/T/D/E]Src kinase substrate motif
  50  [E/D/pT/pY]XpYEESyk kinase substrate motif
  51  [D/E]pYpY[R/K]PTP1B phosphatase substrate motif
  52  EFpY[G/A]TY[G/A]PTP1B phosphatase substrate motif
  53  E[Y/F/D]pYMPTP1B phosphatase substrate motif
  54  E/P[M/L/I/V/F]pY[G/A]X[M/L/I/V/F/Y]APTP1B phosphatase substrate motif
  55  RDXYXTDYpYRPTP1B phosphatase substrate motif
  56  E[F/D/Y]pYPTP1B phosphatase substrate motif
  57  DpYpYRPTP1B, TC-PTP phosphatase substrate motif
  58  [D/E]FpY[G/A][F/Y][A/G]PTPRH phosphatase substrate motif
  59  F[M/L/V/I]pYPTPRJ phosphatase substrate motif
  60  [D/E]X[L/I/V]XpYXX[L/I/V]SHP1 phosphatase substrate motif
  61  [D/E]X[L/I/V]XXpYXX[L/I/V]SHP1 phosphatase substrate motif
  62  [D/E][D/E][D/E/L]XpYXX[F/M/L/V/I][D/E]SHP1 phosphatase substrate motif
  63  [D/E]XpYSHP1 phosphatase substrate motif
  64  [E/P][F/I/L]pYAX[F/I/L/V]SHP1 phosphatase substrate motif
  65  pYIDLSHP2 phosphatase substrate motif
  66  pYASISHP2 phosphatase substrate motif
  67  EFpYAX[V/I]G[R/K/H]SSHP2 phosphatase substrate motif
  68  [D/E][D/E]XXXpYVATC-PTP phosphatase substrate motif
  69  [E/D/Y]pYTC-PTP phosphatase substrate motif

  Binding Motifs       

  Motif described in the literature
(phosphorylated residues in red)		 Features of motif described in the literature Link to original
article describing
the motif
  1  pY[E/M/V][N/V/I]3BP2 SH2 domain binding motif
  2  pYENPAbl SH2 domain binding motif
  3  pYXXPCrk SH2 domain binding motif
  4  pYDHPCrk SH2 domain binding motif
  5  pY[T/A/S][K/R/Q/N][M/I/V/R]Csk SH2 domain binding motif
  6  pY[Y/I/V]N[F/L/I/V]Grb2 SH2 domain binding motif
  7  pYEX[V/I]Fes SH2 domain binding motif
  8  pYEE[I/V]Fgr SH2 domain binding motif
  9  pYEDPFyn SH2 domain binding motif
  10  pY[M/I/L/V]X[M/I/L/V]GRB2, 3BP2, Csk, Fes, Syk C-terminal SH2 domain binding motif
  11  pY[Q/Y/V]N[Y/Q/F]Grb2 SH2 domain binding motif
  12  pYXNGrb2 SH2 domain binding motif
  13  [F/Y]pY[E/T/Y/S]N[I/L/V/P/T/Y/S]GRB7, GRB10 SH2 domain binding motif
  14  pYFX[F/P/L/Y]HCP SH2 domain binding motif
  15  pY[A/E/V][Y/F/E/S/N/V][P/F/I/H]Itk SH2 domain binding motif
  16  pYDYVLck and Src SH2 domain binding motif
  17  pYDEPNck SH2 domain binding motif
  18  pYMXMPI3 Kinase p85 SH2 domain binding motif
  19  pYXXMPI3 Kinase p85 SH2 domain binding motif
  20  pYMPMSPI3 Kinase p85 SH2 domain binding motif
  21  pY[L/I/V]E[L/I/V]PLCgamma C and N-terminal SH2 domain binding motif
  22  pYXXPRasGAP C-terminal SH2 domain binding motif
  23  pYILVX[M/L/I/V/P]RasGAP N-terminal SH2 domain binding motif
  24  TIpYXX[V/I]SAP and EAT2 SH2 domain binding motif
  25  pY[L/V]N[V/P]Sem5 SH2 domain binding motif
  26  pY[T/V/I]XLShb SH2 domain binding motif
  27  pY[I/E/Y/L]X[I/L/M]SHC SH2 domain binding motif
  28  [I/V/L/S]XpYXX[L/I]SHIP2 SH2 domain binding motif
  29  [V/I/L]XpYAX[L/V]SHP1 C-terminal SH2 domain binding motif
  30  XXpYYM[K/R]SHP1 C-terminal SH2 domain binding motif
  31  L[Y/H]pY[M/F]X[F/M]SHP1 N-terminal SH2 domain binding motif
  32  LXpYAXLSHP1 N-terminal SH2 domain binding motif
  33  [I/V]XpYXX[L/V]SHP1 SH2 domain binding motif
  34  [V/I/L]XpY[M/L/F]XPSHP1, SHP2 SH2 domain binding motif
  35  [T/V/I/Y]XpY[A/S/T/V]X[I/V/L]SHP2 CSH2 domain binding motif
  36  [I/L/V][I/L/V][I/L/V/F/T/Y]pY[T/I/L/V][I/L][I/L/V/P]SHP2 C-terminal SH2 domain binding motif
  37  [H/F]XVX[T/S/A]pYSHP2 N-terminal SH2 domain binding motif
  38  [I/V/L]XpY[F/M]XPSHP2 N-terminal SH2 domain binding motif
  39  pY[I/V]X[I/V]SHP2 N-terminal SH2 domain binding motif
  40  [I/L/V/M]XpY[T/V/A]X[I/V/L/F]SHP2 N-terminal SH2 domain binding motif
  41  [I/V]XpY[L/M/T]Y[A/P/T]SGSHP2 N-terminal SH2 domain binding motif
  42  W[M/T/V]pY[Y/R][I/L]XSHP2 N-terminal SH2 domain binding motif
  43  pYIPPSHP2, PLCgamma SH2 domain binding motifs
  44  pYMXMSrc and Abl SH2 domain binding motif
  45  pY[R/K/H/Q/E/D][R/K/H/Q/E/D][I/P]Src, Fyn, Lck, Fgr, Abl, Crk, Nck SH2 domain binding motif
  46  PPXpYSrc, Fyn,Csk, Nck and SHC SH2 domain binding motif
  47  pYEEISrc,Lck and Fyn SH2 domains binding motif
  48  pY[D/E][P/R][R/P/Q]STAT1 SH2 domain binding motif
  49  pYXXQSTAT3 SH2 domain binding motif
  50  pY[M/L/V/I/F][P/R/K/H]QSTAT3 SH2 domain binding motif
  51  pY[Q/T/E][E/Q][L/I]Syk C-terminal SH2 domain binding motif
  52  pYTT[I/L/M]Syk N-terminal SH2 domain binding motif
  53  [D/E]XXXXXXX[D/E]XXpYXXLXXXXXXXYXX[L/I]Syk, ZAP-70, Shc, Lyn SH2 domain binding motif
  54  pYEN[F/I/V]Tensin SH2 domain binding motif
  55  pY[M/L/E]EPVav SH2 domain binding motif
  56  pYESPVav SH2 domain binding motif
  57  D[N/D]XpYCbl PTB domain binding motif
  58  NXLpYDok1 PTB domain binding motif
  59  NXXpYFRIP PTB domain binding motif
  60  NPXpYShc PTB domain binding motif
  61  DDXpYShb PTB domain binding motif
  62  NPXpYFXRShcA PTB domain binding motif
  63  HN[M/L/V/I][M/L/V/I/N]NP[S/T]pYShcC PTB domain binding motif


 
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