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Serine / Threonine motifs
 

  Kinase / Phosphatase motifs          

  Motif described in the literature
(phosphorylated residues in red)
Features of motif described in the literature Link to original
article describing
the motif
  1  RXRXX[pS/pT][F/L]Akt kinase substrate motif
  2  RXRXX[pS/pT]Akt kinase substrate motif
  3  GRART[S/T]pSFAEAkt kinase substrate motif
  4  [R/Q/K][R/K/N/Q/P/H][R/K][R/S/T][N/K/Q/H/D/P]pS[F/W/I/M/N/S][S/T/H][R/S/K][S/T/P/Q]Akt kinase substrate motif
  5  [R/K]X[R/K][S/T]XpSAkt kinase substrate motif
  6  [M/V/L/I/F][R/K/H]XXX[pS/pT]XXX[M/V/L/I/F]AMP-activated protein kinase substrate motif
  7  [M/V/L/I]XX[R/K/H]X[pS/pT]XXX[M/V/L/I]AMP-activated protein kinase substrate motif
  8  [M/V/L/I/F][R/K/H]XX[pS/pT]XXX[M/V/L/I/F]AMP-activated protein kinase substrate motif
  9  [R/K]XRXXpSXXX[R/K]AMP-activated protein kinase 2 substrate motif
  10  [P/L/I/M]X[L/I/D/E]pSQATM kinase substrate motif
  11  LpSQEATM kinase substrate motif
  12  pSQATM kinase substrate motif
  13  [R/K/N]RX[pS/pT][M/L/V/I]Aurora-A kinase substrate motif
  14  [D/E][pS/pT]XXX b-Adrenergic Receptor kinase substrate motif
  15  HpSTSDD Branched chain alpha-ketoacid dehydrogenase kinase substrate motif
  16  YRpSVDEBranched chain alpha-ketoacid dehydrogenase kinase substrate motif
  17  [M/V/L/I/F]XRXX[pS/pT]XXX[M/V/L/I/F]Calmodulin-dependent protein kinase I substrate motif
  18  [M/I/L/V/F/Y]XRXX[pS/pT][M/I/L/V/F/Y]Calmodulin-dependent protein kinase II alpha substrate motif
  19  RXX[pS/pT]Calmodulin-dependent protein kinase II substrate motif
  20  [K/F][R/K][Q/M][Q/M/K/L/F]pS[F/I/M/L/V][D/E/I][L/M/K/I][F/K]Calmodulin-dependent protein kinase II substrate motif
  21  [M/V/L/I/F]X[R/K]XX[pS/pT]XXCalmodulin-dependent protein kinase II substrate motif
  22  RXXpSCalmodulin-dependent protein kinase II substrate motif
  23  VPGKARKKpSSCQLLCalmodulin-dependent protein kinase IV substrate motif
  24  PLARTLpSVAGLPCalmodulin-dependent protein kinase IV substrate motif
  25  [M/I/L/V/F/Y]XRXX[pS/pT]Calmodulin-dependent protein kinase IV substrate motif
  26  E[F/E]D[T/A/G]GpSI[I/F/Y/G][I/G/F][F/G][F/P/L]Casein Kinase I delta substrate motif
  27  Y[Y/E][D/Y][A/D][A/G]pSI[I/Y/F/G][I/G/F][F/G][F/P/L]Casein Kinase I gamma substrate motif
  28  pS*PXX[pS/pT]Casein Kinase I substrate motif
  29  [D/E]XX[pS/pT]Casein Kinase I substrate motif
  30  [pS/pT]XX[S/T]Casein Kinase I substrate motif
  31  [pS/pT]XXX[S/T][M/L/V/I/F]Casein Kinase I substrate motif
  32  [E/D/A][D/E][E/D][E/D]pS[E/D/A][D/E/A][E/D][E/D]Casein Kinase II substrate motif
  33  pS*X[E/pS/pT]Casein Kinase II substrate motif
  34  pS*XX[E/pS/pT]Casein Kinase II substrate motif
  35  [pS/pT]XX[E/D]Casein Kinase II substrate motif
  36  pSDXECasein kinase II substrate motif
  37  pSXX[E/D]Casein kinase II substrate motif
  38  pS[D/E]X[D/E]X[D/E]Casein Kinase II substrate motif
  39  [D/E]pS[D/E]X[D/E]Casein Kinase II substrate motif
  40  pS[D/E][D/E][D/E]Casein Kinase II substrate motif
  41  [pS/pT]XX[D/E]Casein Kinase II substrate motif
  42  [pS/pT]*XX[E/D/pS/pY]Casein Kinase II substrate motif
  43  [S/E/P/G][D/S/N/E/P][E/D/G/Q/W][Y/E/D/S/W/T][W/E/D]pS[D/E][D/E/W/N][E/D][E/D/N/Q]Casein Kinase II substrate motif
  44  [R/K]pSP[R/P][R/K/H]Cdc2 kinase substrate motif
  45  [pS/pT]PX[R/K]Cdc2 kinase substrate motif
  46  HHH[R/K]pSPR[R/K]RCdc2 kinase substrate motif
  47  PX[pS/pT]PKKXKKCdc2 like protein kinase substrate motif
  48  [pS/pT]PX[R/K]CDK1,2, 4, 6 kinase substrate motif
  49  pSPX[R/K]XCDK kinase substrate motif
  50  PL[pS/pT]PIP[K/R/H]CDK4 kinase substrate motif
  51  PL[pS/pT]PX[K/R/H] CDK4 kinase substrate motif
  52  pTPXKCDK5 kinase substrate motif
  53  [K/H/G]H[H/P][K/G/H]pSP[R/K][H/R/K][R/H/K]CDK5 kinase substrate motif
  54  [pS/pT]PG[pS/pT]PGTPCDK5 kinase substrate motif
  55  [M/I/L/V]X[R/K]XX[pS/pT]Chk1 kinase substrate motif
  56  RXX[pS/pT]XXRCLK1 kinase substrate motif
  57  [R/K]X[R/K]X[R/K]XpSXXRCLK1,2 kinase substrate motif
  58  R[R/H][R/H][R/E]RE[R/H]pSR[R/D]LCLK2 kinase substrate motif
  59  KKXRRpT[L/V]XDMPK1 kinase substrate motif
  60  KKRXRpT[L/V]XDMPK1 kinase substrate motif
  61  [R/K]XRRX[pS/pT][L/V]XDMPK1 kinase substrate motif
  62  RXX[pS/pT][L/V]RDMPK1,2 kinase substrate motif
  63  XpSQDNA dependent Protein kinase substrate motif
  64  P[pS/pT]XDNA dependent Protein kinase substrate motif
  65  R[R/K]R[E/R]R[E/A][H/R]pSRR[R/D][L/E]DOA/CDC-like kinase 2 substrate motif
  66  [I/L/V/F/M]RRXX[pS/pT][I/L/M/V/F]Doublecortin kinase-1 kinase substrate motif
  67  EXpSXRXXRelF2 alpha kinase substrate motif
  68  [T/P/S][G/P/E/Y][P/L/I][L/M/P]pSP[G/P/F][P/F/G/Y][F/Y/I]ERK1 kinase substrate motif
  69  pTEpYERK1 Kinase substrate motif
  70  PX[pS/pT]PPERK1,2 kinase substrate motif
  71  XXPX[pS/pT]PPPXERK1,2 kinase substrate motif
  72  PX[pS/pT]PERK1, ERK2 Kinase substrate motif
  73  pSPERK1, ERK2 Kinase substrate motif
  74  KpSPPERK1, ERK2, SAPK, CDK5 and GSK3 kinase substrate motif
  75  [D/Y/W/E][C][P/S/C/E][P/C/S/L/T/V][L/M/T]pS[P/A][T/S/G/R/C/F][W/P/S][W/F]ERK2 kinase substrate motif
  76  XX[pS/pT]EG protein-coupled receptor kinase 1 substrate motif
  77  X[pS/pT]XXX[A/P/S/T] G protein-coupled receptor kinase 1 substrate motif
  78  [pS/pT]PX[K/R]Growth associated histone HI kinase substrate motif
  79  [K/R][pS/pT]PGrowth associated histone HI kinase substrate motif
  80  [pS/pT]P[K/R]Growth associated histone HI kinase substrate motif
  81  pS*XXXpSGSK3 kinase substrate motif
  82  PXpTPGSK3, Erk1, Erk2 and CDK5 kinase motif
  83  RXXpSPVGSK-3, ERK1, ERK2, CDK5 substrate motif
  84  K[pS/pT]PXKGSK-3, ERK1, ERK2, CDK5 substrate motif
  85  KpSPXXXKGSK-3, ERK1, ERK2, CDK5 substrate motif
  86  KpSPXXKGSK-3, ERK1, ERK2, CDK5 substrate motif
  87  KpSPXXXXKGSK-3, ERK1, ERK2, CDK5 substrate motif
  88  KpTPAKEEGSK-3, ERK1, ERK2, CDK5 substrate motif
  89  PXpSPGSK-3, ERK1, ERK2, CDK5 substrate motif
  90  X[pS/pT]PGSK-3, ERK1, ERK2, CDK5 substrate motif
  91  XXpSPGSK-3, ERK1, ERK2, CDK5 substrate motif
  92  [M/L/V/I/F][R/K/H]XXSXXX[M/L/V/I/F]HMGCoA Reductase kinase substrate motif
  93  GP[Q/M]pSPIJNK1 Kinase substrate motif
  94  LRpTLKB1 Kinase substrate motif
  95  [R/K]XRXXpSMAPKAPK1 kinase substrate motif
  96  RRRXpSMAPKAPK1 kinase substrate motif
  97  [L/F/I]XXXR[Q/S/T]L[[pS/pT][M/L/I/V]MAPKAPK2 kinase substrate motif
  98  XXBXRXXpSXXMAPKAPK2 kinase substrate motif
  99  pSXXX[pS/pT]MAPKAPK2 kinase substrate motif
  100  pT*[G/P/E]pYMAPK 11,13,14 Kinase substrate motif
  101  RRFGpSBRRFMEKK kinase substrate motif
  102  RRFGpS[M/L/V/I/F]RR[M/L/V/I/F]MEKK kinase substrate motif
  103  KKRXXpSX[R/K][R/K]MLCK kinase substrate motif
  104  FpTYmTOR kinase substrate motif
  105  IRRLpSTRRRNek 2 kinase substrate motif
  106  [R/N][F/L/M][R/K][R/K]pS[R/I/V/M][R/I/M/V][M/I/F/V][I/F/M]NIMA kinase substrate motif
  107  FRX[pS/pT]NIMA kinase substrate motif
  108  RF[R/K][R/K]pS[R/I][R/I]MINIMA kinase substrate motif
  109  [R/K]XRXX[pS/pT][M/L/V/I]p70 Ribosomal S6 kinase substrate motif
  110  VFLGFpTYVAPp70 Ribosomal S6 kinase substrate motif
  111  AKRRRLSpSLRAPAK1 kinase substrate motif
  112  VRKRpTLRRLPAK1 kinase substrate motif
  113  [R/K][R/X]X[pS/pT]PAK2 kinase substrate motif
  114  FXXF[pS/pT][F/Y]PDK1 kinase substrate motif
  115  KRKQIpSVRPhosphorylase kinase substrate motif
  116  [F/M/K][R/K][M/R/Q/F][M/F/L/I]pS[F/I/M/L][F/R/K][L/I][F/L/I]Phosphorylase kinase substrate motif
  117  [K/R]XXpS[V/I]Phosphorylase kinase substrate motif
  118  [R/K][R/K][R/K]X[pS/pT]XPim1 kinase substrate sequence
  119  [R/K][R/K/A/Q/P][R/K][R/Q/H/N/Y][P/H/K]pS[G/S/T][P/S/G/Q/H/S/T][S/P/Q/G/D][T/S/P/G]Pim2 kinase substrate sequence
  120  RRXpS[M/I/L/V/F/Y]PKA kinase substrate motif
  121  RXpSPKA kinase substrate motif
  122  KRXXpSPKA kinase substrate motif
  123  RXXpSPKA kinase substrate motif
  124  [R/K]X[pS/pT]PKA kinase substrate motif
  125  KXX[pS/pT]PKA kinase substrate motif
  126  [R/K][R/K]X[pS/pT]PKA kinase substrate motif
  127  KXXX[pS/pT]PKA kinase substrate motif
  128  [pS/pT]X[R/K]PKA kinase substrate motif
  129  RRRRpSIIFIPKA kinase substrate motif
  130  RRXpSPKA kinase substrate motif
  131  R[R/K]X[pS/pT][I/L/V/F/Y][D/C/X]XDPKA kinase substrate motif
  132  RRXpSPKA kinase substrate motif
  133  RRR[R/N]pSII[F/D]PKA kinase substrate motif
  134  [R/C/P/K][R/A/P][R/K][R/K/S][N/L/S/M/P]Ps[I/L/V/C][S/P/H/Q][S/W/Q][S/L/G]PKA kinase substrate motif
  135  R[R/K]X[pS/pT]BPKA, PKG kinase substrate motif
  136  ARKGpSLRQPKC alpha kinase substrate motif
  137  R[R/F]RR[R/K]GpSF[R/K][R/K]PKC alpha kinase substrate motif
  138  [L/R/F][R/K]R[K/Q]GpS[F/M]KKXAPKC beta kinase substrate motif
  139  RXRKGpSFPKC delta kinase substrate motif
  140  KRQGpSVRRPKC epsilon kinase substrate motif
  141  R[K/E/R]XpSPKC epsilon kinase substrate motif
  142  ARXXR[R/K]RpSFRRPKC eta kinase substrate motif
  143  FXXF[pS/pT][F/Y]PKC family kinase substrate motif
  144  RRRK[G/K]SF[R/K][R/K]KAPKC gamma kinase substrate motif
  145  XRXX[pS/pT]XRXPKC kinase substrate motif
  146  [pS/pT]X[R/K]PKC kinase substrate motif
  147  [R/K]XX[pS/pT]PKC kinase substrate motif
  148  [R/K]XX[pS/pT]X[R/K]PKC kinase substrate motif
  149  [K/R]X[pS/pT]PKC kinase substrate motif
  150  [R/K]X[pS/pT]X[R/K]PKC kinase substrate motif
  151  [L/V][V/L/A]R[Q/K/E]MpSPKC mu kinase substrate motif
  152  [R/F/W/M][W/A/K/S][R/S/K/H][R/H/S/Q][R/K/N/P/G/Q]pS[I/F/R/V/K/S/L/M][K/M/R/S/T][R/S/K/W][R/K/G]PKC theta kinase substrate motif
  153  FXRXXpS[F/M][F/M]PKC zeta kinase substrate motif
  154  [L/V/I][R/K/Q][R/K][R/K/T/Q/M][N/K/R/L/M/H]pS[F/W/I/M/L/V][S/N][R/S/P/Y/W][S/R/N/L]PKD kinase substrate motif
  155  R[R/K]X[pS/pT]BPKG kinase substrate motif
  156  RXX[pS/pT]XRXXRPKR kinase substrate motif
  157  [D/E]X[pS/pT][I/L/V/M]X[D/E]Plk1 kinase substrate motif
  158  XpSXXDXXPyruvate dehydrogenase kinase substrate motif
  159  PLpTLPRAF1 kinase substrate motif
  160  PLLpTPRAF1 kinase substrate motif
  161  PLpTPRAF1 kinase substrate motif
  162  PpTLPRAF1 kinase substrate motif
  163  PLpTLPRAF1 kinase substrate motif
  164  PpTLPRAF1 kinase substrate motif
  165  LpTPRAF1 kinase substrate motif
  166  KKKKKK[pS/pT]XXXTGF beta receptor kinase substrate motif
  167  [R/K/Q/N][M/C/W][R/T/S/N][E/D/S/N][R/K/E/D/N]pS[S/D/E][S/GC/D][SM/R/N][N/H/S/R/C]TGF beta receptor kinase substrate motif
  168  RRXXpSZIP kinase substrate motif
  169  KRXRpSZIP kinase substrate motif
  170  KRRXpTZIP kinase substrate motif
  171  pTEYDual specificity protein phosphatase 1 substrate motif
  172  pT*XpYDual specificity protein phosphatase 6 substrate motif
  173  RRA[pS/pT]VAPP2A, PP2C substrate motif
  174  XRXXpSVAPP2B substrate motif
  175  XpT*XpYXPP2C delta substrate motif

  Binding Motifs       

  Motif described in the literature
(phosphorylated residues in red)
Features of motif described in the literature Link to original
article describing
the motif
  1  KCSpTWP14-3-3 domain binding motif
  2  RXXpS14-3-3 domain binding motif
  3  RXRXXpSXP14-3-3 domain binding motif
  4  YpTV14-3-3 domain binding motif
  5  RSX[pS/pT]XP14-3-3 domain binding motif
  6  RX[Y/F]XpSXP14-3-3 domain binding motif
  7  RPVSSAApSVY14-3-3 domain binding motif
  8  pS[D/E][D/E]EBARD1 BRCT domain binding motif
  9  DpS*GXXpS*Beta-TrCP1 domain binding motif
  10  pS[F/Y/H][V/F/Y][F/Y]BRCA1 BRCT domain binding motif
  11  [I/L][I/L/P]pTP[R/K]CDC4 WD40 domain binding motif
  12  HFDpTYLIChk2 FHA domain binding motif
  13  [R/D/H][L/Y][L/M][K/A]pT[Q/L/M/E/V][K/L/I/R]FHA domain binding motif
  14  S[pS/pT]XMDC1 BRCT domain binding motif
  15  S[pS/pT]XPlk1 PBD domain binding motif
  16  pSYIIRAD9 BRCT domain binding motif
  17  [pS/pT]PWW domain binding motif


 
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